As an infectious disease specialist, Dr. Gregory House (Hugh Laurie) is a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives. House solves the inexplicable cases that other doctors cannot understand.
House isn't alone in this quest. His team includes neurologist Dr. Eric Foreman (Omar Epps), a neurologist with a troubled youth and a desire to avoid becoming as abrasive as House; immunologist Dr. Allison Cameron (Jennifer Morrison) - who sometimes cares too much and has conflicting feelings about House; and Dr. Robert Chase (Jesse Spencer), a specialist in intensive care who has lived a very privileged life. House's good (and possibly only) friend Dr. James Wilson (Robert Sean Leonard) is an oncology specialist, who has to help and stand up for House on a regular basis, while trying to get him to face a few harsh truths.